The market holds a critical unmet need for treating SporadicInclusion Body Myositis (sIBM) in several patients since the disease often getsundiagnosed inspite of robust diagnostic measures available in the market.
There is also need for therapies which will drive the sporadic inclusion body myositis (sIBM) in market thereby meeting the demands of the patients. Overall, the Sporadic Inclusion Body Myositis (sIBM) therapeutics market is further expected to increase by the major drivers such as rising prevalent population, technological advancements, and upcoming therapies in the forecast period [2020–2030]
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As initial off-label treatment, some sIBM patients receiveimmunosuppressive treatment like prednisone which is helpful in patient withactive inflammation in muscles as it inhibits leukocyte infiltration at the site of inflammation, interfere in the function of mediators of inflammatory response, suppression of humoral immune responses.
Another drug used is IVIG (Intravenous Immunoglobulin) which interacts with a number of different components of the immune system, including cytokines, complement, Fc receptors and several cell surface immune competent molecules which further impacts different effector cells of the immune system.
Another corticosteroid immunosuppressive treatments includeglucocorticoids like cyclophosphamide which attach to alkyl groups to DNA bases, resulting in the fragmented DNA by repair enzymes and replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA.
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