DelveInsight’s ‘Chronic smell and flavor loss Market Insights, Epidemiology and Market Forecast– 2030’ report delivers an in-depth understanding of the CVU, historical and forecasted epidemiology as well as the CVU market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.
The Chronic smell and flavor loss market report research provides current treatment practices, emerging drugs, and market share of the individual therapies, current and forecasted 7MM CVU market size from 2017 to 2030. The report also covers current CVU treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the market.
Chronic vein ulceration (CVU) is a defect in the skin below the level of the knee that occurs due to improper functioning of venous valves, persisting for more than six weeks with no tendency to heal after three or more months. Hence, also known as leg ulcers or lower limb ulcers or venous ulcers, or venous insufficiency or stasis ulcer.cancerous or cells along the lining of the colon or rectum mutate and grow out of control, forming a tumor.
The venous abnormality that leads to venous leg ulceration may involve abnormalities at different locations in the venous system, of different extent, and different etiologies. Possible causes of venous ulcers include inflammatory processes resulting in leukocyte activation, endothelial damage, platelet aggregation, and intracellular edema.
Venous ulcers are often recurrent, and open ulcers can persist from weeks to many years. Severe complications include cellulitis, osteomyelitis, and malignant change. Although the overall prevalence is relatively low, the refractory nature of these ulcers increase the risk of morbidity and mortality and have a significant impact on patient quality of life.
The pathophysiology of venous ulcers is not entirely clear. Venous incompetence and associated venous hypertension are thought to be the primary mechanisms for ulcer formation. Factors that may lead to venous incompetence include immobility; ineffective pumping of the calf muscle; and venous valve dysfunction from trauma, congenital absence, venous thrombosis, or phlebitis.
Risk factors for venous ulcers include varicose veins, history of blood clots in the legs (deep vein thrombosis), blockage of the lymph vessels, which causes fluid to build up in the legs, older age, being female, or being tall, family history of venous insufficiency, obesity, pregnancy, smoking, sitting or standing for long periods (usually for work) and fracture of a long bone in the leg or other serious injuries, such as burns or muscle damage. The symptoms of a venous ulcer include pain, itching, and swelling in the affected area. There may also be discolored, or hardened skin around the ulcer, and the sore may produce a foul-smelling discharge
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